Genetic Predictors to Acupuncture Response for Arthralgia Induced by Aromatase Inhibitors in Patients With Breast Cancer

  • STATUS
    Recruiting
  • End date
    Nov 30, 2023
  • participants needed
    59
  • sponsor
    Affiliated Hospital of Qinghai University
Updated on 27 November 2021
metastasis
anastrozole
exemestane
letrozole

Summary

Purpose:Acupuncture for arthralgia induced by aromatase inhibitors in patients with breast cancer associated with screening of SNPs.

Description

Aromatase inhibitor-induced arthralgia (AIA) is the most common side effect of aromatase inhibitors (AIs) used in breast cancer , may cause poor adherence to AIs. Studies have shown that acupuncture has a certain therapeutic effect on AIA in breast cancer. In this study, acupuncture was used to relieve the symptoms of arthralgia in patients, and the efficacy of acupuncture was observed by using relevant scales. Currently, studies have shown that AIA in breast cancer patients is related to some biological factors.

At the same time, we collected peripheral blood samples of patients, combined with the reported relevant literature, screened out the single nucleotide polymorphisms(SNP) related to AIA and to guide acupuncture treatment of aromatase Inhibitors induced arthralgia, balance the toxicity of endocrine therapy, and improve compliance and effectiveness.

Details
Condition Breast Cancer, breast carcinoma, cancer, breast, Breast Cancer Diagnosis
Treatment Acupuncture group
Clinical Study IdentifierNCT05125432
SponsorAffiliated Hospital of Qinghai University
Last Modified on27 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

History of stage I-III breast cancer and free of disease by clinical examination;Currently receiving aromatase inhibitors (Anastrozole, Letrozole, or Exemestane) treatment
AI-assisted treatment has lasted for more than one month, and there are obvious symptoms of arthralgia
Voluntarily participate in the clinical trial and sign the informed consent form after informed consent (patients voluntarily accept the treatment and give informed consent)
Eastern Cooperative Oncology Group (ECOG) score of physical condition (0-1)
Patients with previous local recurrence were eligible, but not patients with distant metastasis
The basic indexes were consistent, and the blood routine and ECG were normal

Exclusion Criteria

Patients with needle phobia
Low platelet count (<50000); comorbidity with a bleeding disorder; comorbidity with thyroid dysfunction; pregnancy; haemoglobin levels <10 g/dl and haematocrit <30; anaemia on active pharmacological treatment orreceiving blood transfusion or steroids
Lymphoedematous of limbs
Patients have a history of acupuncture treatment for 6 months
Patients were reluctant to participate in the study
A prior history of inflammation, metabolic disease, or neurotic joints, except for previous treatment with bisphosphonates, steroids, or opioid analgesics
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