Repetitive Transcranial Magnetic Stimulation for Lower Limb Spasticity in Multiple Sclerosis Patients

  • STATUS
    Recruiting
  • End date
    Dec 25, 2023
  • participants needed
    40
  • sponsor
    University of Belgrade
Updated on 25 November 2021
fatigue
spasticity
disease or disorder

Summary

Leg spasticity is common problem encountered with a large proportion of patients suffering with multiple sclerosis (MS) with an increasing severity as the disease progresses. It mostly affects the antigravity muscles that significantly complicates transfer, increases fatigue and makes walking more difficult. Hence, leg spasticity often interferes with patients' mobility and significantly influences their quality of life. A great number of multidisciplinary rehabilitation studies has shown a significant effect of numerous specific functional changes in patients with secondary (SP) and primary progressive (PP) MS but there are no reviews related to spasticity. The positive therapeutic effect of modulating Transcranial Magnetic Stimulation ( TMS) methods on spasticity is shown in only two studies, in patients with relapse remitting clinical form in the remission phase of the disease. The effect of TMS on clinical measures of lower limb spasticity, functional inability and the quality of life in patients with SPMS and PPMS will be examined in this study. The objective to this study are to to explore whether rTMS boosted exercise therapy (ET) treatment can bring more improvement in lower limb spasticity than ET treatment alone in these patients.

Details
Condition Dermatite Atopique modérée ou grave, multiple sclerosis (ms), Multiple Sclerosis, Radiologically Isolated Syndrome
Treatment transcranial magnetic stimulation, Conventional exercise
Clinical Study IdentifierNCT02747914
SponsorUniversity of Belgrade
Last Modified on25 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Confirmed clinical form of SPMS and PPMS (established on the basis of the revised McDonald criteria)
EDDS score 2-6.5
lower limb spasticity caused by MS
years age of the patient 65. years

Exclusion Criteria

clinical worsening of the disease over the past 30 days
the presence of pregnancy, dementia, alcoholism, history of loss of consciousness, epilepsy, metal objects in the head, pacemakers and other electronic devices in the body at a distance of 20cm from the top of the patients head, serious associate diseases (malignancy, heart disease)
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