Partially Hydrolyzed Guar Gum (PHGG) for Amelioration of Chronic Obstructive Pulmonary Disease (COPD)

  • STATUS
    Recruiting
  • End date
    Dec 31, 2023
  • participants needed
    60
  • sponsor
    Fu Jen Catholic University Hospital
Updated on 26 November 2021
Accepts healthy volunteers

Summary

Some components of the diet could promote the growth of certain bacterial strains present in the intestine, which are closely associated with benefits for host health. An intestinal commensal Parabacteroides goldsteinii (Pg) was highlighted to be significantly negatively associated with severity of COPD. Furthermore, the investigators identify the potential prebiotics (PHGG) which may enrich the abundance of P. goldsteinii and increase the probiotic effect of P. goldsteinii.

The investigators designed a randomized control study, which enroll adults diagnosed with COPD. Then the two groups will receive PHGG or not. Stool samples will be collected. The ameliorative efficacy will be evaluated by questionnaire and lung function test. Intestinal microbiota and metabolome will be analyzed and the correlation with lung function indices will be further investigated.

Description

It is well known that some components of the diet could promote the growth of certain bacterial strains present in the intestine, which are closely associated with benefits for host health. In the previous study, the investigators found that an intestinal commensal Parabacteroides goldsteinii (Pg) was highlighted to be significantly negatively associated with severity of COPD. Furthermore, the investigators identify the potential prebiotics (PHGG) which may enrich the abundance of P. goldsteinii and increase the probiotic effect of P. goldsteinii. However, the effect of PHGG supplement on compositional and functional properties of the human microbiota with COPD still remains unclear.

In this proposal, the investigators designed a randomized control study, which enroll adults diagnosed with COPD. The investigators will review their past medical records and related image and lung function test. Then the two groups will receive PHGG or not. Stool samples will be collected. The ameliorative efficacy will be evaluated by questionnaire and lung function test. Intestinal microbiota and metabolome will be analyzed and the correlation with lung function indices will be further investigated. In the future, it may be used to investigate and analyze the change of microbiota and metabolome, then develop possible treatment options of COPD.

Details
Condition respiratory tract disease, chronic obstructive pulmonary disease, Microbial Colonization, Respiratory Tract Diseases, chronic obstructive pulmonary disease (copd), Reactive Airway Disease, Chronic Obstructive Lung Disease, COPD (Chronic Obstructive Pulmonary Disease), COPD
Treatment Partially Hydrolyzed Guar Gum (PHGG)
Clinical Study IdentifierNCT05126654
SponsorFu Jen Catholic University Hospital
Last Modified on26 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

age of 40-85 years
diagnosis of COPD made by pulmonologist
provision of written informed consent

Exclusion Criteria

severe and unstable comorbidities or active malignancy
COPD exacerbation within the 4 weeks prior
cognitive impairment or a psychiatric disorder
pregnancy
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