Cervical Cancer Screening by Self-sampling in a Cohort of Younger Women in Ethiopia

  • End date
    Sep 24, 2024
  • participants needed
  • sponsor
    Lund University
Updated on 24 November 2021
cancer screening
diagnostic procedures
cervical cancer screening
cervical dysplasia
human papilloma virus vaccine
cervical intraepithelial neoplasia
cervical intraepithelial neoplasms
Accepts healthy volunteers


The overall purpose of the project is to evaluate an algorithm for an HPV self-sampling based cervical cancer screening algorithm in a mid-size town in Ethiopia that could be applicable for nationwide implementation in low and middle-income countries (LMIC).

Specific aims are the following:

  • To evaluate the algorithm using Visual Inspection with Acetic acid (VIA) and VIA together with Lugol's Iodine (VILI) as triage and to use HPV self-sample to follow up those treated and those with persisting HPV.
  • To evaluate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae and their effect on the quality of VIA.
  • To determine immune response profiles in high-risk HPV-positive women who cleared, persisted, or developed Cervical Intraepithelial Neoplasia 2/3 (CIN).
  • To assess how specific cervicovaginal microbiota compositions are associated with HPV infection, cervical dysplasia, and cancer

Condition Viral infection, Disorders of cervix NOS, carcinoma of cervix, sexually transmitted diseases, cervical cancer, uterine, Papillomaviridae, STI, carcinoma of the cervix uteri, Human Papilloma Virus (HPV), Metagenome, Venereal disease, Uterine Cancer, Gynecological Infections, sexually transmitted infections, sexually transmitted disease, Viral Infections, Sexually Transmitted Diseases (STDs), Cervical Cancer, Female Genital Diseases, carcinoma of the cervix, microbiota, Human Papilloma Virus, cancer of the cervix, Sexually Transmitted Infection, cervix cancer, Uterine Serous Carcinoma, cervical carcinoma
Treatment VIA (Visual Inspection with Acetic acid) and VILI (Visual Inspection with Lugol's Iodine), VIA (Visual Inspection with Acetic acid)
Clinical Study IdentifierNCT05125380
SponsorLund University
Last Modified on24 November 2021


Yes No Not Sure

Inclusion Criteria

Can give consent, Age above 18

Exclusion Criteria

Women who have undergone hysterectomy
Clear my responses

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