Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment

  • End date
    May 31, 2023
  • participants needed
  • sponsor
    Lawson Health Research Institute
Updated on 24 November 2021
advanced lung cancer
endobronchial ultrasound
lung carcinoma
small lung


This study will investigate the role of sampling suspicious chest lymph nodes with a procedure called endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA) or transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) in patients planned to receive radical dose radiation.

This study will use Stereotactic Ablative Radiotherapy (SABR) for treatment methods. SABR is a newer radiation treatment that delivers high-dose, precise radiation to small tumors and can be delivered more accurately than with older radiation treatment methods. It is considered a standard treatment for small lung cancers, and select cancers that have spread to the brain.

The purpose of this study is to compare if the lymph node sampling procedure is valuable for determining the extend of nodal disease in metastatic Non-Small Cell Lung Cancer (NSCLC) compared to imaging alone.

Condition Non-Small Cell Lung Cancer, nsclc
Treatment Endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA), Transesophageal ultrasound-guided fine needle aspiration (EUS-FNA)
Clinical Study IdentifierNCT04852588
SponsorLawson Health Research Institute
Last Modified on24 November 2021


Yes No Not Sure

Inclusion Criteria

Patients with oligometastatic non-small cell lung cancer (NSCLC), including a primary lung tumour ( hilar/mediastinal adenopathy) with up to 5 synchronous metastases
Radical treatment intent to all sites is recommended at multi-disciplinary tumour board or by discussion by medical oncologist and radiation oncologist and/or surgeon
Age 18 years or older
Good performance status (Eastern Cooperative Oncology Group [ECOG 0-1) with life-expectancy of at least 6 months as determined by enrolling physician
Patient has undergone staging investigations less than 3 months prior to registration
Positron Emission Tomography (PET) / Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) brain (CT brain with contrast if contraindication to MRI) OR
CT chest/abdomen, radionucleotide bone scan and MRI of brain (CT brain with contrast if contraindication to MRI)
Pathologic confirmation of NSCLC

Exclusion Criteria

Contraindication to Endobronchial Ultrasound (EBUS) / Endoscopic Ultrasound (EUS)
Unable to provide consent for EBUS/EUS
Contraindication to chest radiotherapy
Pregnant or lactating women
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