A Study to Evaluate JAK Inhibitor Cream in EGFR-inhibitor-induced Skin Rash

  • STATUS
    Recruiting
  • participants needed
    24
  • sponsor
    Shanghai East Hospital
Updated on 21 May 2022

Summary

Epidermal growth factor receptor inhibitors (EGFRIs) are widely used targeted agents that have been approved for the treatment of various tumor types. In some clinical studies with EGFRIs, the incidence of dermatology AE, the skin rash, is reportedly as high as 95%, which profoundly impact the patients' quality of life. However no treament for onset skin rash has been approved to be effective by any clinical trial yet. Janus kinase (JAK) inhibitor, has been approved for or studied in a variety of skin conditions such as alopecia areata, atopic dermatitis, and psoriasis. Thus the investigators intend to evaluate the efficacy and safety of JAK inhibitor cream for the treatment of EGFRIs-induced skin rash in cancer patients.

Details
Condition Dermatosis, Congenital Skin Diseases, Skin Conditions, Acneiform Eruption
Treatment Vehicle cream, Cream containing JAK Inhibitor
Clinical Study IdentifierNCT05120362
SponsorShanghai East Hospital
Last Modified on21 May 2022

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