The Effectiveness of Antimicrobial Breathing System on the Presence of Multidrug-resistant Organisms

  • STATUS
    Recruiting
  • days left to enroll
    27
  • participants needed
    200
  • sponsor
    Fu Jen Catholic University
Updated on 25 November 2021

Summary

The aim of this study is to investigates the effectiveness of antimicrobial breathing system on multidrug-resistant organisms (MDRO).

Description

Background

Cross transmission via skin contact and environmental media is the main route for common outbreak of health care-associated infection which more likely to be improved or prevented by infection control program. Silver Knight uses silver ions to disrupt the normal enzymatic activities of bacteria for reducing microbial growth within, and on, the surface of the breathing systems. It functions as a safe, quick and effective catalyst to deactivate pathogenic bacteria and prevent their proliferation. However, there was no study comparing the standard ventilator circuit with Silver Knight. This study focuses on the effectiveness of antimicrobial breathing system in MDRO which including carbapenem-resistant, vancomycin-resistant and multi-drug resistant.

Study Design:

This is a prospective, randomized study in a single hospital in the intensive care unit.

Methods

In this study, we conduct a cluster-randomized crossover, multicenter trial. There are two

groups
  1. Control group: standard ventilator circuit in odd number month.
  2. Experimental group: Silver Knight in even number month This study is expected to recruit 200 subjects. During this period, the ventilator circuits are all routinely used, only the tubing will not be discarded after use for specimen collection.And the MDRO on the surfaces of ventilator circuits will be analyzed and evaluated.
Effect

We expect the antimicrobial breathing system could be more effectively than the standard ventilator circuit. The policy related to current ventilator circuit will be revised according to the results of this study.

Key words:

Antimicrobial Breathing system, ventilator circuits, multidrug-resistant organisms (MDRO)

Details
Condition Bacterial Contamination
Treatment Silver Knight
Clinical Study IdentifierNCT04927806
SponsorFu Jen Catholic University
Last Modified on25 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

mechanical ventilators in Medisive CareUnit (MICU)

Exclusion Criteria

Using ventilators for less than seven days
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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