The CARMA Technique Study

  • End date
    Nov 23, 2026
  • participants needed
  • sponsor
    Princess Alexandra Hospital, Brisbane, Australia
Updated on 23 November 2021
endoscopic resection
narrow band imaging


Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers, remains a problem this most commonly stems from unrecognised incomplete polyp resection. Thus, a standardised endoscopic technique is needed that will allow endoscopists to consistently achieve a clear margin of resection. The investigators believe the Cap Assisted Resection Margin Assessment (CARMA) technique will address this problem. This novel technique focuses on a standardised assessment of the resection margin after endoscopic polypectomy utilising available standard high-definition video endoscopes with imaging features including narrow band imaging (NBI) and magnification endoscopy.

Condition COLONIC POLYP, Colon Polyps, Colonic Sessile Serrated Lesion
Treatment CARMA technique
Clinical Study IdentifierNCT05099432
SponsorPrincess Alexandra Hospital, Brisbane, Australia
Last Modified on23 November 2021


Yes No Not Sure

Inclusion Criteria

any polypectomy (though only a maximum of two polyps from one individual participant)

Exclusion Criteria

polyps less than 10mm which were resected under endoscopic view with a definite > 1mm clear margin
scar site recurrence polyps
polyps with endoscopic evidence of invasion
pedunculated polyps
participants who will not be available for follow up endoscopy
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