Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy

  • End date
    Aug 31, 2023
  • participants needed
  • sponsor
    Balgrist University Hospital
Updated on 23 April 2022
postoperative pain
Accepts healthy volunteers


The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after periacetabular osteotomy.


Bernese periacetabular osteotomy (PAO) is a standard procedure with good mid and long-term results. Postoperative pain is a great concern and postoperative pain management of great importance. High demand for opiates and the associated side effects especially nausea limit the postoperative rehabilitation.

Promising results to reduce postoperative pain and nausea have been achieved by perioperative dexamethasone, which has a strong anti-inflammatory effect reducing pain and inflammation as well as a strong anti-emetic effect, especially in total hip replacement.

It is our goal to compare the effect of perioperative intravenous dexamethasone (3x 4mg Amp. Fortecortin =12mg prior to surgery and 3x4mg Amp. Fortecortin = 12mg at 8.00am of the first postoperative day) to a control group (placebo) (3ml saline solution postoperative day 1 at 8.00am) regarding pain level, opiate consumption, postoperative nausea and patient satisfaction.

A double-blinded prospective randomized control trial including up to 60 patients receiving elective unilateral PAO will be conducted.

Condition Pain, Postoperative Nausea, Amount of Postoperative Opioid Use in Milligrams
Treatment Nacl 0.9%, Dexamethasone 4 Mg/mL Injectable Solution
Clinical Study IdentifierNCT05120076
SponsorBalgrist University Hospital
Last Modified on23 April 2022


Yes No Not Sure

Inclusion Criteria

Age ≥ 18 years
General anasthesia
Elective periacetabular osteotomy for any reason
Written informed consent as documented by signature (Appendix Informed Consent Form)
Competent German language skills

Exclusion Criteria

Chronic pain patient, chronic lower back pain
Steroid or immunosuppressive drugs used within 6 months of surgery
Renal failure, hepatic failure
Relevant allergies
Pregnancy/ Breast feeding
Contraindications for Fortecortin treatment according to Swissmedic
Previous enrollment into the current study
Participation in another study with investigational drug within the 30 days preceding and during the present study
Known or suspected non-compliance, drug or alcohol abuse Illness according to "Warnings and Precautions of Dexamethasone and NaCl
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note