Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery (TRICS-IV)

  • End date
    Jan 12, 2024
  • participants needed
  • sponsor
    Unity Health Toronto
Updated on 12 March 2022
cardiopulmonary bypass


TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

Condition Disorder, Heart, Postoperative, Cardiac Surgery
Treatment Restrictive Transfusion Strategy, Liberal Transfusion Strategy
Clinical Study IdentifierNCT04754022
SponsorUnity Health Toronto
Last Modified on12 March 2022


Yes No Not Sure

Inclusion Criteria

≥18 and ≤65 years of age
Planned cardiac surgery using cardiopulmonary bypass
Informed consent obtained
Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more

Exclusion Criteria

Patients who refuse participation
Patients who are unable to receive or who refuse blood products
Patients who are involved in a preoperative autologous pre-donation program
Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential)
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