Monitoring Minimal Residual Disease in Gastric Cancer by Liquid Biopsy Study Description

  • STATUS
    Recruiting
  • End date
    Oct 1, 2024
  • participants needed
    100
  • sponsor
    University Medical Center Ho Chi Minh City (UMC)
Updated on 11 May 2022
gastrectomy
tumor markers
gastric adenocarcinoma
lymphadenectomy
cancer chemotherapy
adenocarcinoma

Summary

This study aims to evaluate the use of Next Generation Sequencing (NGS) to detect circulating tumor DNA in gastric cancer patients after gastrectomy

Description

Gastric cancer is the fourth most common cancer in Vietnam with high mortality rate. Patients at early stages undergo radical gastrectomy with curative intent, but the remaining tumor cells, termed as minimal residual disease (MRD), can later cause relapse. Conventional methods to monitor MRD such as imaging and blood tests for biomarkers such as CEA are not sensitive and specific enough. ctDNA has recently emerged as a promising noninvasive marker with high accuracy to monitor MRD and detect relapse in many cancers such as breast and colorectal cancers. However, its application in gastric cancer has not been extensively evaluated. Therefore, this study aims to use advanced NGS technologies to detect ctDNA in liquid biopsy as a biomarker to monitor MRD after radical gastrectomy.

Details
Condition Gastric Cancer, ctDNA
Treatment ctDNA
Clinical Study IdentifierNCT05029869
SponsorUniversity Medical Center Ho Chi Minh City (UMC)
Last Modified on11 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Male or Female patients aged 18 years and older
Histologically proven primary gastric adenocarcinoma before surgery
Clinical stage is locally advanced cT2-4a any N and M0
In initial evaluation, patient can undergo radical gastrectomy and lymphadenectomy
No preoperative therapy, including chemotherapy and radiotherapy
No known cancer diagnosis within last five years
Signed informed consent

Exclusion Criteria

Gastrectomy cannot be achieved during operation due to metastasis
Patient fails to follow-up and provide postoperative samples
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