Outcomes of Breast Conservative Surgery for Post Chemotherapy Tumour Size After Response to Neoadjuvant Chemotherapy

  • STATUS
    Recruiting
  • End date
    Dec 1, 2024
  • participants needed
    1
  • sponsor
    Assiut University
Updated on 20 November 2021
Accepts healthy volunteers

Summary

Breast cancer is the most common cancer among women. The morbidity and mortality of breast cancer are much higher than those observed with other female cancers (1). The incidence of breast cancer increases with age (2, 3). Approximately 1.7 million new cases are estimated to occur worldwide, and mortality is increasing in developing countries, primarily because the disease is not diagnosed until it is in an advanced stage(4) Neoadjuvant chemotherapy (NACT) is considered the standard of care for the management of locally advanced breast cancer and although this treatment has historically been reserved for those with inoperable breast cancer now is increasingly being used for women with earlier stage disease. (5). Encouraging results obtained with neoadjuvant chemotherapy in have resulted in clinicians using preoperative chemotherapy for patients with smaller tumors(6) . Neoadjuvant chemotherapy (NACT) could reduce surgical morbidity of the breast and axilla. By down staging of the tumor, NACT can convert patients who are candidates for mastectomy to breast-conserving surgery (BCS) candidates [7]. Furthermore, it has potential to reduce excision volumes in patients with large tumors who are already candidates for BCS. Another surgical advantage is down staging of the axilla so that axillary lymph node dissection can be avoided (8).

Complete pathological response after neoadjuvant systemic treatment is high, while complete clinical response rates are even higher. Because it is difficult to localize the original tumor bed after a complete clinical and radiological response, marking the tumor before the start of neoadjuvant systemic treatment is required to enable breast-conserving surgery afterward. Achieving adequate margins of excision is an important component of breast surgery. Local recurrence rates are significantly higher for patients who have positive margins of excision (9) some prospective and retrospective data suggested that patients with BCT after neoadjuvant therapy may have an increased risk for the development of a local recurrence .

If this were true, there would be no further advantage of neoadjuvant therapy and this treatment option could be questioned altogether.

A common question raised with respect to performing breast-conserving therapy after neoadjuvant chemotherapy is the volume of breast tissue that should be resected

Description

Study subjects:

  1. Inclusion criteria:
  2. Female patients with operable breast cancer
  3. Female Patient aged from 20 to 60 years old
  4. Patients who are fit for general anesthesia.
  5. Patients who provide a written informed consent.
  6. Patient who agree to provide short term outcome data and agree to provide contact information to provide contact information.
  7. Exclusion criteria:
  8. Female patients less than 20 years old
  9. Stage 4 breast cancer
  10. Patient has no pathological or clinical response to NACT
  11. Patients who are contraindicated for radiotherapy
  12. Pregnant patients in first trimester
  13. Patient with inflammatory carcinoma
  14. Sample Size Calculation:

Prospective trial study include 50 patient whom fulfilled the inclusion criteria 2.4.4 -Study tools (in detail, e.g., lab methods, instruments, steps, chemicals, ): This prospective study is including patients will be diagnosed breast cancer and will receive neoadjuvant chemotherapy .

All patients underwent a preoperative clinical evaluation including physical examination (PE), ultrasonography, mammograph and MRI then biopsies of the breast tumor were performed to determine the histological subtype and receptor status Methods

Pro-operative preparation:

After confirming diagnosis of breast cancer and its molecular type patient undergoing marking the tumor and axillary lymph nodes by clips before receiving neoadjuvant chemotherapy.

Making Virtual pre-operative breast conserving surgical technique based on the previous tumor size

The Surgical steps:

  • Depending on new tumor size ,site of the tumor ,breast cup size and degree of breast ptosis ;oncoplastic breast conserving technique would be selected
  • A prophylactic antibiotic as first generation cephalosporin is given intravenous.
  • Skin preparation by povidine iodine.
  • Excision of the mass with safety margin.
  • Sentinel axillary lymph node or complete axillary clearance depend on axillary lymph node status
  • All specimens were oriented with sutures
  • A frozen section examination of the specimen was performed intraoperative
  • When the margin status was inadequate, a re-excision was performed
  • Closure as drawn by different oncoplastic technique

Details
Condition Safety of Excision the New Tumor Size
Treatment breast conservative surgery for post chemotherapy tumour size
Clinical Study IdentifierNCT05115279
SponsorAssiut University
Last Modified on20 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

a. Inclusion criteria
Female patients with operable breast cancer
Female Patient aged from 20 to 60 years old
Patients who are fit for general anesthesia
Patients who provide a written informed consent
Patient who agree to provide short term outcome data and agree to provide contact information to provide contact information

Exclusion Criteria

Exclusion criteria
Female patients less than 20 years old
Stage 4 breast cancer
Patient has no pathological or clinical response to NACT
Patients who are contraindicated for radiotherapy
Pregnant patients in first trimester
Patient with inflammatory carcinoma
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