A Study to Evaluate the Efficacy and Safety of Proxalutamide (GT0918) in Hospitalized COVID-19 Subjects

  • STATUS
    Recruiting
  • days left to enroll
    44
  • participants needed
    762
  • sponsor
    Suzhou Kintor Pharmaceutical Inc,
Updated on 8 July 2022

Summary

This study is an adaptive Phase III randomized double-blind placebo-controlled trial to evaluate the efficacy and safety of Proxalutamide (GT0918) in hospitalized adults diagnosed with COVID-19. The study is a multicenter trial that will be conducted globally. The study will compare GT0918 plus standard of care (SOC) with the placebo plus SOC. Approximately 762 subjects will be randomized in a 1:1 ratio to either GT0918 plus SOC or placebo plus SOC group.

Description

Coronavirus disease 2019 (COVID-19) emerged in late 2019 and spread rapidly, resulting in a global pandemic.SARS-CoV-2 encodes nonstructural and structural proteins required for its viral life cycle. Among them, the spike glycoprotein plays a pivotal role in SARS-CoV-2 infection by recognizing and attaching to ACE2 transmembrane protein on host cells. Kintor protocol has been designed to evaluate efficacy and safety of GT0918 in hospitalized subjects with COVID-19 illness. The target population of this study are hospitalized subjects with COVID-19 illness with positive SARS-CoV-2 virus test within 72 hours of randomization. The study will evaluate anti-androgen therapy may effectively prevent progression to the more severe form of COVID-19 illness and death, shorten the time to sustained recovery and decrease the mortality rate. Subject will receive either GT0918 plus standard of care or matched placebo plus standard of care. GT0918/placebo will be given 300mg orally once a day around 30 minutes after meal for 7 days and can be extended up to 14 days per investigator discretion

Details
Condition Covid19
Treatment Standard of Care, Matching Placebo, GT0918
Clinical Study IdentifierNCT05009732
SponsorSuzhou Kintor Pharmaceutical Inc,
Last Modified on8 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Subject (or legally authorized representative) provides informed consent prior to initiation of any study procedures
Subject (or legally authorized representative) understands and agrees to comply with planned study procedures
Male and non-pregnant female subjects with age ≥18 years of age at the time of randomization
Admitted to a hospital with symptoms suggestive of severe COVID-19
Has laboratory-confirmed SARS-CoV-2 infection as determined by PCR or other commercial or public health assay (including rapid antigen test) in any specimen, as documented by either of the following
PCR positive in sample collected < 72 hours prior to randomization; OR
PCR positive in sample collected ≥ 72 hours prior to randomization, documented inability to obtain a repeat sample (e.g. due to lack of testing supplies, limited testing capacity, results taking > 24 hours, etc) AND progressive disease suggestive of ongoing SARS-CoV-2 infection
Illness of any duration, and at least one of the following
Shortness of breath, RR≥30 /minute
Clinical signs indicative of progressive aggravation, lung radiographic infiltrates by imaging (chest x-ray, CT scan, etc.) showing >50% progression within 24-48 hours
PaO2/FiO≤300mmHg 1mmHg=0.133kPa
Resting state SpO2 ≤ 93% on room air
Total Abstinence (when this is in line with the preferred and usual lifestyle of the patient. Periodic abstinence (e.g. calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception, or
All women of childbearing potential defined as any female who has experienced menarche
Use of one of the following combinations (a+b or a+c or b+c)
and who has not undergone surgical sterilization (hysterectomy or bilateral
oophorectomy) and is not postmenopausal. Highly effective contraception
Use of oral, injected or implanted hormonal methods of contraception or other forms of hormonal contraception that have comparable efficacy (failure rate < 1%), for example hormone vaginal ring or transdermal hormone contraception
methods
Placement of an intrauterine device (IUD) or intrauterine system (IUS)
Barrier methods of contraception: Condom or Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal suppository
include
Male sterilization (at least 6 months prior to screening). For female subjects on the study, the vasectomized male partner should be the sole partner for that subject
In case of use of oral contraception women should have been stable for a minimum of 3 months before taking study treatment. Women are considered post-menopausal and not of childbearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy) or tubal ligation at least six weeks ago. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment, is she considered not of childbearing potential
Female sterilization (have had prior surgical bilateral oophorectomy with or
Agree not to participate in another clinical trial for the treatment of COVID-19 through Day 60 after first dose
without hysterectomy) or tubal ligation at least six weeks before taking study
treatment. In case of oophorectomy alone, only when the reproductive status of
the woman has been confirmed by follow-up hormone level assessment
Regardless of their fertility status, male subjects must agree to either remain
abstinent (if this is their preferred and usual lifestyle) or use condoms as
well as one additional highly effective method of contraception (less than 1%
failure rate) or effective method of contraception with nonpregnant women of
childbearing potential partners for the duration of the study and until 90
days after the last dose. A condom is required to be used also by vasectomized
men in order to prevent delivery of the drug via seminal fluid

Exclusion Criteria

Subjects are excluded from the study if any of the following criteria apply
ALT/AST > 3 times the upper limit of normal
Serum total bilirubin > 1.5 x ULN (upper limit of normal)
Estimated glomerular filtration rate (eGFR) < 30 ml/min (including patients receiving hemodialysis or hemofiltration)
Subjects with significant cardiovascular disease as following
Pregnancy or breast feeding
Anticipated discharge from the hospital or transfer to another hospital which is not a study site within 72 hours
Allergy to any study medication
Suspected serious, active bacterial, fungal, viral, or other infection (besides COVID-19) that in the opinion of the investigator could constitute a risk when taking investigational product
Have a history of VTE (deep vein thrombosis [DVT] or pulmonary embolism [PE]) within 12 weeks prior to screening or have a history of recurrent (>1) VTE (DVT/PE)
Subject taking or had taken an anti-androgen of any type including androgen depravation therapy, 5-alpha reductase inhibitors, etc. within 3 months before dosing
Have participated, within the last 30 days before dosing, in a clinical study involving an investigational intervention. If the previous investigational intervention has a long half-life, 5 half-lives or 30 days, whichever is longer, should have passed
heart failure NYHA class ≥3 ii. left ventricular ejection fraction <50% iii. those with a history of cardiac arrhythmias, including long QT syndrome
Neutropenia (absolute neutrophil count <1000 cells/μL) (<1.0 x 10^3/μL)
Is admitted to Intensive Care Units at randomization
Lymphopenia (absolute lymphocyte count <200 cells/μL) (<0.20 x 10^3/μL)
Received monoclonal antibody, convalescent plasma, or intravenous immunoglobulin [IVIg]) for COVID-19 withing 14 days of screening
Subjects with active myopathy
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