ANALYSIS OF INFLAMMATORY REACTIONS OBSERVED IN BRONCHOALVEOLAR LAVAGES (BALS)

  • STATUS
    Recruiting
  • End date
    Feb 17, 2024
  • participants needed
    34
  • sponsor
    Centre Chirurgical Marie Lannelongue
Updated on 18 November 2021
cancer
lung cancer
lung carcinoma

Summary

Immunological toxicities associated with immune checkpoint inhibitor (ICI) monoclonal antibodies are unpredictable autoimmune and inflammatory pathologies that can affect all treated patients. Some of these events are severe and occur in 15-20% of patients treated with Programmed Death 1 (PD-1) antibodies.

The study of cellular immunological characteristics within tissues affected by toxicities and the interactions between the different actors of these toxicities aims at improving the knowledge concerning the mechanisms of these toxicities, but also at being able to specify the unexpected effects of ICIs on cells of the immune system, outside the tumor microenvironment.

Diffuse infiltrative lung disease is one of the most frequent and severe toxicities encountered in patients treated with anti PD-(L)1; either for bronchial cancer, melanoma or any other type of cancer. Patients developing this type of complication benefit from cytological, bacteriological, mycological and molecular analyses of intra-alveolar constituents obtained by bronchoalveolar lavage (BAL) performed during bronchial fibroscopy as part of their routine care. These analyses help to confirm the diagnosis of alveolitis, to specify the cellular characteristics of alveolar inflammation and to eliminate differential diagnoses of ICI toxicity.

Details
Condition carcinoma lung, Pulmonary Disease, Lung Neoplasm, Lung Disease, lung carcinoma, Bronchial Neoplasm, Lung Cancer
Treatment treatment with immunotherapy and diffuse infiltrative lung disease, Patients requiring carcinologic lobectomy
Clinical Study IdentifierNCT05117372
SponsorCentre Chirurgical Marie Lannelongue
Last Modified on18 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult subject ( 18 years old)
Patient having consented to the research
Group 1
Patient with cancer who was treated with immunotherapy
Appearance of CT lung abnormalities during immunotherapy, not related to cancer
With high suspicion of infiltrative lung disease
Pneumopathy (CTCAE version 5 classification)
Patients requiring bronchial fibroscopy with BAL
Groups 2
Patient with lung cancer with peripheral tumor
Requires surgical pulmonary lobectomy in the operating room

Exclusion Criteria

Patient treated or having been treated in the last 2 months with corticosteroid therapy
Patient treated with immunosuppressant and/or cyclophosphamide, and/or Anti-TNF in the last 12 months
Absence of consent
Patient under curatorship, guardianship or safeguard of justice
Pregnant woman
Group 1
Patient with respiratory failure
Groups 2
Patient with lung cancer with proximal or endobronchial tumor
Patients requiring bilobectomy or pneumonectomy
Patient who has been treated with immunotherapy
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