A Phase 1b, Open Label, Global, Multicenter, Dose Determination, Randomized Dose Expansion Study to Determine the Maximum Tolerated Dose, Assess the Safety and Tolerability, Pharmacokinetics and Preliminary Efficacy of Iberdomide (CC-220) in Combination With R-CHOP-21 and CC-99282 in Combination With R-CHOP-21 for Subjects With Previously Untreated, Aggressive B-cell Lymphoma
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- STATUS
- Recruiting
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- End date
- Feb 4, 2026
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- participants needed
- 116
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- sponsor
- Celgene
Summary
This is a Phase 1b study consisting of 2 parts: a dose escalation (Part 1) of CC-220 or CC-99282 added to the standard R-CHOP-21 regimen for first-line treatment of a-BCL. The dose escalation (Part 1) will consist of 2 parallel arms in combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP-21); CC-220 and R-CHOP-21 or CC-99282 and R-CHOP-21. Part 1 will be followed by a randomized dose expansion (Part 2) with CC-220 and/or CC-99282 at the Recommended Phase 2 Dose (RP2D) in combination with R-CHOP-21.
Details
| Condition | Lymphoma, B-Cell |
|---|---|
| Treatment | Rituximab, cyclophosphamide, prednisone, vincristine, doxorubicin, CC-220, CC-99282 |
| Clinical Study Identifier | NCT04884035 |
| Sponsor | Celgene |
| Last Modified on | 25 October 2022 |
Eligibility
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