Effect of Blenderized Enteral Tube Feeds on Pediatric Upper Gastrointestinal Tract Physiology

  • STATUS
    Recruiting
  • End date
    Feb 18, 2024
  • participants needed
    45
  • sponsor
    Boston Children's Hospital
Updated on 18 November 2021

Summary

Blenderized diets consist of a wide range of table foods such as fruits, vegetables, meat and legumes, pureed in a blender and administered via gastrostomy tube. In a recent study, the investigators reported that children receiving blenderized feeds via gastrostomy had fewer total admissions and respiratory admissions, total emergency room visits, and improved gastrointestinal symptom scores compared to those fed formula. The goal of this project is to understand how these diets affect gastroesophageal reflux burden.

Description

The investigators hypothesize that rates of gastroesophageal reflux will be lower in blenderized diets compared to formula. The investigators will determine if reflux burden as measured by multichannel intraluminal impedance/esophageal pH monitoring performed for clinical purposes differs between low viscosity conventional formula, medium viscosity commercial blenderized diet, and high viscosity commercial blenderized diet in 45 children receiving conventional formula via gastrostomy. All participants will receive each of the three test diets in random order in a 3-way crossover design. Results of gastric emptying scans will be recorded if done for clinical purposes.

Details
Condition Enteral Feeding Intolerance
Treatment Nourish, Elecare Jr, Real Foods Blends
Clinical Study IdentifierNCT04900597
SponsorBoston Children's Hospital
Last Modified on18 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 1-21 years
G-tube
Able to tolerate bolus gastric feeds over 30 minutes
Use of conventional enteral formula
Undergoing impedance study for clinical purposes

Exclusion Criteria

History of allergy or intolerance to any component of the test diets
History of Nissen fundoplication
Current use of non-invasive pressure support (continuous or bi-level positive airway pressure)
Clear my responses

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