A Study of Focal Salvage High-Dose-Rate Brachytherapy for Prostate Gland Only Recurrence

  • End date
    May 31, 2023
  • participants needed
  • sponsor
    University of Rochester
Updated on 17 November 2021


The purpose of this study is to learn more about what effects the use of high-dose-rate (HDR) brachytherapy on prostate cancer recurrence, seen by AXUMIN PET scan, has on prostate cancer.


In this study the investigator would like to better understand the use of high-dose rate (HDR) brachytherapy to target only recurrent prostate cancer that can be seen by AXUMIN PET scan. The use of HDR brachytherapy for prostate cancer is not new, but it is a more recent advancement to use it to treat only what can be seen instead of the whole prostate.

Condition Malignant neoplasm of prostate, Prostate Disorders, Prostatic disorder, hdrs, prostate carcinoma, Prostate Cancer, Prostate Cancer, Early, Recurrent, prostate cancers
Treatment High-Dose-Rate Brachytherapy
Clinical Study IdentifierNCT04645810
SponsorUniversity of Rochester
Last Modified on17 November 2021


Yes No Not Sure

Inclusion Criteria

History of histologically confirmed, clinically localized adenocarcinoma of
the prostate treated with external beam radiation, brachytherapy, or
combination of external beam radiation and brachytherapy, with curative intent
completed at least 24 months ago F-18 fluciclovine (AXUMIN) PET scan within 90
days prior to registration demonstrating recurrent lesion within the prostate
gland Biopsy confirmation of disease recurrence within the prostate gland Age
KPS 70% Suitable candidate for brachytherapy based on established criteria
IPSS score <16 No pelvic arch interference No Rectal fistula/fissure Fit for
general or spinal anesthesia No history of urethral stricture Ability to
understand, and willingness to sign the written informed consent

Exclusion Criteria

Evidence of metastatic or nodal disease outside of the prostate gland on
AXUMIN PET scan within 90 days prior to enrollment Patient unable to have MRI
Patients with neuroendocrine or small cell carcinoma of the prostate TURP
within 6 months prior to enrollment History of Crohn's disease, ulcerative
colitis, or known radiation proctitis Inability to understand spoken and
written English
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