Role of A2A Receptor in Hypercholesterolemic Patients

  • STATUS
    Recruiting
  • End date
    Jun 15, 2023
  • participants needed
    150
  • sponsor
    Assistance Publique Hopitaux De Marseille
Updated on 15 November 2021
atherosclerosis
cardiovascular disease
hypercholesterolemia
endothelial dysfunction
ezetimibe
cholesterol measurement
hmg-coa reductase inhibitors
pcsk9
Accepts healthy volunteers

Summary

Hypercholesterolemia promotes chronic inflammation, endothelial dysfunction, atherosclerosis and is a major risk factor for cardiovascular disease (CVD). Treatment with lipid-lowering drugs (statins, ezetimibe, PCSK9 inhibitors or LDL-apheresis) reduces the risk of major cardiovascular events in proportion to the absolute reduction of LDL-cholesterol (LDL-C). Nevertheless, a better understanding of the effects of hypercholesterolemia on the cardiovascular and immune systems could help identify all the mechanisms responsible for the excess risk of CVD in hypercholesterolemic patients and develop better prevention and treatment strategies.

Adenosine via A2A receptors (A2AR) plays a crucial role in the regulation of the cardiovascular and immune systems.

In this project, the investigators wish :

  • To study whether the expression and function of A2AR in PBMCs are altered in human hypercholesterolemia, using as a study model a larger cohort of patients with hypercholesterolemia of increasing level and severity: polygenic form, heterozygous genetic form and homozygous genetic form in comparison with healthy subjects with normal cholesterol levels.
  • To study whether A2AR expression and function in PBMCs are associated with blood levels of LDL-C and homocysteine and with the inflammatory status of patients.
  • To assess whether the cholesterol-lowering therapies currently used to reduce LDL-C levels and thus the risk of CVD in hypercholesterolemic patients have an impact on possible alterations of A2AR expression and function in PBMCs.

Details
Condition Hyperlipidemia, High Cholesterol, Hypercholesterolemia, elevated cholesterol, High Cholesterol (Hyperlipidemia), hypercholesteremia
Treatment Blood sample
Clinical Study IdentifierNCT05017649
SponsorAssistance Publique Hopitaux De Marseille
Last Modified on15 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Male or female subjects aged 18-80 years
For the group of hypercholesterolemic patients
LDL-cholesterol level >1.9 g/L with or without treatment to make the diagnosis of hypercholesterolemia (laboratory test less than 12 months old at inclusion)
For the healthy group
No cholesterol-modifying therapy
Subject not having hypercholesterolemia (biological assessment less than 12 months old at inclusion with LDL-cholesterol level < 1.9 g/L) and not taking cholesterol-lowering treatment
Subjects who are affiliated or beneficiaries of a social security plan
Subject agreeing to participate in the study and having signed an informed consent

Exclusion Criteria

Protected person, as defined by articles L1121-5, L1121-6 and L1121-8 of the Public Health Code: pregnant or breastfeeding woman, person deprived of liberty by judicial decision, adult person unable to give consent
Person who does not understand the French language
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