Study on the Risks of Symptomatic Dengue on Pregnancy

  • End date
    Mar 14, 2024
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire de la Réunion
Updated on 14 November 2021
Accepts healthy volunteers


Dengue fever is the most common arbovirus worldwide (390 million people infected per year) and is a global public health problem. This public health problem is also becoming European due to its rapid expansion over the past decade with an increase in cases of 400% and the appearance of the first indigenous cases of dengue in Europe. Studies on the consequences of dengue fever on pregnancy find contradictory results. In fact, most of these studies are observational studies describing the risk of dengue fever for pregnancy, without comparison with a control group or comparing the different pregnancy morbidities to those found during pregnancy in the general population. Other research is retrospective case-control studies with major biases in the definitions of obstetric complications, which makes the results questionable.

The study therefore proposes to carry out a prospective case-control study with rigorous matching criteria, strict definitions of cases, controls and obstetric complications.

Condition Dengue, Pregnancy, dengue fever
Treatment Data Collection
Clinical Study IdentifierNCT04826081
SponsorCentre Hospitalier Universitaire de la Réunion
Last Modified on14 November 2021


Yes No Not Sure

Inclusion Criteria

Pregnant patients
Affiliated with social security
Symptomatic or pauci-symptomatic dengue
Biological confirmation of dengue fever
Inclusion Criteria for the control
Pregnant patients
Affiliated with social security

Exclusion Criteria

Multiple pregnancy
Patient's refusal
Protected persons: person deprived of liberty by judicial or administrative decision, minor, and person subject to a legal protection measure: guardianship or curators)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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