Multi-model Image of Immunosuppressive Agents in TAO

  • End date
    Dec 1, 2025
  • participants needed
  • sponsor
    Sun Yat-sen University
Updated on 24 November 2021


This study aims to evaluate the efficacy of immunosuppressive agents treating Thyroid Associated Ophthalmopathy by multi-model image.


Thyroid Associated Ophthalmopathy is one of autoimmune orbital diseases characterized by enlargement of the extraocular muscles and increase in fatty or/and orbit connective tissue volume affecting the appearance and visual function of the eyes. TAO can be classified into active phase and inactive phase according to the activity score and wait-and-see or surgery are widely chosen for patients in inactive phase. A great number of patients in inactive phase becoming refractory and reoccurring.

Until now, the improvement of TAO is still be measured subjectively with low reliability and less accuracy. Multi-modal image is a new method to assess both the appearance and visual function of TAO and some of the indexes can be regarded as more apparent and stable in assessing the efficacy and prognosis of TAO.

This perspective cohort study aims to evaluate the efficacy of immunosuppressive agents in TAO by multi-model image and function assessments.

Condition Graves' ophthalmopathy
Treatment Immunosuppressive Agent
Clinical Study IdentifierNCT05110040
SponsorSun Yat-sen University
Last Modified on24 November 2021


Yes No Not Sure

Inclusion Criteria

Informed consent
Age 18-70 years old
Diagnosed with TAO

Exclusion Criteria

Contraindications to immunosuppressive agents
Patients with HIV, Hepatitis B or C, Tuberculosis or other active significant infection
Patients with severe chronic diseases in heart, lung, kidney and liver, which make it not tolerant to immunosuppressive agents
Patients have contraindications of MRI(metal pacemaker, fake teeth, foreign body and other materials which will disturb the examination)
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