Prospective Study on the Risks of Dengue Fever for the Fetus.

  • STATUS
    Recruiting
  • End date
    Mar 11, 2023
  • participants needed
    150
  • sponsor
    Centre Hospitalier Universitaire de la Réunion
Updated on 11 November 2021

Summary

Dengue is the most common arbovirus worldwide (390 million people infected each year) and belongs to the Flavivirus genus of the Flaviviridae family like Zika. Its expansion has been rapid since the last decade with an increase in the number of cases of 400% and the first cases of indigenous dengue described in Europe.

Current data on the consequences of dengue fever on the fetus are incomplete. The risk of maternal-fetal transmission of dengue during the peripartum period has now been recorded in numerous case reports and a few case series for patients who contracted dengue in the 12 days preceding childbirth or at the time of delivery. However, the transmission of dengue is highly variable depending on the studies ranging from 1.6 to 15% and the consequences for the newborn are very variable ranging from simple thrombocytopenia to death in severe neonatal dengue.

Regarding the risk of malformation, a few old cases of heart disease, hydrocephalus and neural tube closure abnormalities have been described in the literature following exposure to dengue fever during pregnancy. Since no malformative case has been described, however, to our knowledge, no prospective study with specialized ultrasound monitoring has been performed for pregnant women who contracted dengue during their pregnancy.

Details
Condition Dengue, dengue fever
Treatment Data Collection
Clinical Study IdentifierNCT04822441
SponsorCentre Hospitalier Universitaire de la Réunion
Last Modified on11 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Pregnant patients
Major
Affiliated with social security
Symptomatic or pauci-symptomatic dengue
Biological confirmation of dengue fever by dengue positive PCR or IgM positive during the current dengue episode

Exclusion Criteria

Multiple pregnancy
Patient's refusal
Protected persons: person deprived of liberty by judicial or administrative decision, minor, and person subject to a legal protection measure: guardianship or curators)
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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