Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages

  • End date
    Jan 7, 2024
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire de Besancon
Updated on 14 November 2021


Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).

Condition Inflammation
Treatment blood sample or joint fluid or gingival exudate
Clinical Study IdentifierNCT05106075
SponsorCentre Hospitalier Universitaire de Besancon
Last Modified on14 November 2021


Yes No Not Sure

Inclusion Criteria

Age Limits (18-80 years)
Information and non-opposition for participating in the study
Patients suffering from periodontitis grade III ou IV
Patients suffering from microcristalline arthritis
patient with health insurance

Exclusion Criteria

patient under corticotherapy
non-compliant patient
patient with no health insurance
patient in exclusion period from an other study
legal incapacity
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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