Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages
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- STATUS
- Recruiting
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- End date
- Jan 7, 2024
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- participants needed
- 20
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- sponsor
- Centre Hospitalier Universitaire de Besancon
Summary
Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).
Details
| Condition | Inflammation |
|---|---|
| Treatment | blood sample or joint fluid or gingival exudate |
| Clinical Study Identifier | NCT05106075 |
| Sponsor | Centre Hospitalier Universitaire de Besancon |
| Last Modified on | 14 November 2021 |
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