4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension

  • End date
    Oct 19, 2023
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire, Amiens
Updated on 19 November 2021
right heart catheterization
pulmonary arterial pressure


Due to radiation exposure and low but real risk of morbidity and mortality associated with right heart catheterization, non-invasive procedures to estimate mPAP are desired for the diagnosis of PH or to monitor treatment effectiveness. Echocardiography is used as a screening tool to estimate systolic pulmonary arterial pressure (sPAP), but due various limitations, this technique is not considered to be sufficiently accurate for the diagnosis of PH. The aim of 4D flow MRI is to evaluate the complete time-varying tridirectional velocity field in a volume of interest. It enables flow and velocity measurements in a vascular region of interest and visualization of vector plots of blood flow velocity fields. Previous studies have shown on the one hand, correlations between mPAP and hemodynamic parameters obtained by phase contrast MRI and, on the other hand, appearance of a vortical blood flow in the pulmonary artery in PH. More studies are required to confirm 4D MRI as a valuable tool for mPAP estimation in PH.

Following screening echocardiography, all patients will undergo right heart catheterization for PH assessment. Then, all patients will be referred for a complete cardiac MRI exam with the addition of a 4D Flow sequence (does not require supplementary injection of a contrast agent and does not extend the duration of the examination) followed promptly (within the same hour) by a Doppler-echocardiography. The data from each examination will be blindly interpreted from the results of the other one. No follow-up will be required for the study.

Condition Recurrent Pregnancy Loss, Functional Dyspepsia, Effects of Chemotherapy, Memory Problems, Infantile Fibrosarcoma, Pulmonary Arterial Hypertension, Renal Anemia, Pseudobulbar Affect, Stasis Dermatitis, Joint Injuries, Myopic Macular Degeneration, echocardiograms, Anemic Cancer, right heart catheterization, Echocardiography, Gambling Problems, Chronic Renal Anemia, Catheter Complications, sound measurement, Open Heart Surgery, Cancer Treatment, Habit Reversal, Testotoxikose, Partial Medial Meniscectomy, Chronic Pelvic Pain, Nerve Injury, transthoracic echocardiography, Primary Insulin Hypersecretion, Cancer Prevention, Low Testosterone, Serial Evaluation of Ductal Epithelium, Mental Disability, Surviving Abuse, Spine Athroplasty, Complicated Grief, Spinocerebellar Disorders, Dental Filling, Severe Premenstrual Symptom, heart ultrasound, Pulmonary Hypertension, Pelvic Adhesions, Late Infantile Neuronal Ceroid Lipfuscinsosis, Magnetic Resonance Imaging, pulmonary arterial pressure, Indikation: Diabetes - Typ II, Abdominal Surgery
Treatment 4D-flow sequence
Clinical Study IdentifierNCT05103189
SponsorCentre Hospitalier Universitaire, Amiens
Last Modified on19 November 2021


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Inclusion Criteria

Age 18 years old
Patient referred for cardiac MRI who previously underwent right heart catheterization for pulmonary hypertension assessment
Affiliation to a social security program
Ability of the subject to understand and express opposition

Exclusion Criteria

Age <18 years old
Major obesity (> 140 kg) not allowing the patient to enter the tunnel of the machine whose diameter is less than 70 cm
Person under guardianship or curators
Pregnant woman
Allergy to gadolinium chelates
Any contraindications to MRI
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