4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension
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- STATUS
- Recruiting
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- End date
- Oct 19, 2023
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- participants needed
- 57
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- sponsor
- Centre Hospitalier Universitaire, Amiens
Summary
Due to radiation exposure and low but real risk of morbidity and mortality associated with right heart catheterization, non-invasive procedures to estimate mPAP are desired for the diagnosis of PH or to monitor treatment effectiveness. Echocardiography is used as a screening tool to estimate systolic pulmonary arterial pressure (sPAP), but due various limitations, this technique is not considered to be sufficiently accurate for the diagnosis of PH. The aim of 4D flow MRI is to evaluate the complete time-varying tridirectional velocity field in a volume of interest. It enables flow and velocity measurements in a vascular region of interest and visualization of vector plots of blood flow velocity fields. Previous studies have shown on the one hand, correlations between mPAP and hemodynamic parameters obtained by phase contrast MRI and, on the other hand, appearance of a vortical blood flow in the pulmonary artery in PH. More studies are required to confirm 4D MRI as a valuable tool for mPAP estimation in PH.
Following screening echocardiography, all patients will undergo right heart catheterization for PH assessment. Then, all patients will be referred for a complete cardiac MRI exam with the addition of a 4D Flow sequence (does not require supplementary injection of a contrast agent and does not extend the duration of the examination) followed promptly (within the same hour) by a Doppler-echocardiography. The data from each examination will be blindly interpreted from the results of the other one. No follow-up will be required for the study.
Details
| Condition | Recurrent Pregnancy Loss, Functional Dyspepsia, Effects of Chemotherapy, Memory Problems, Infantile Fibrosarcoma, Pulmonary Arterial Hypertension, Renal Anemia, Pseudobulbar Affect, Stasis Dermatitis, Joint Injuries, Myopic Macular Degeneration, echocardiograms, Anemic Cancer, right heart catheterization, Echocardiography, Gambling Problems, Chronic Renal Anemia, Catheter Complications, sound measurement, Open Heart Surgery, Cancer Treatment, Habit Reversal, Testotoxikose, Partial Medial Meniscectomy, Chronic Pelvic Pain, Nerve Injury, transthoracic echocardiography, Primary Insulin Hypersecretion, Cancer Prevention, Low Testosterone, Serial Evaluation of Ductal Epithelium, Mental Disability, Surviving Abuse, Spine Athroplasty, Complicated Grief, Spinocerebellar Disorders, Dental Filling, Severe Premenstrual Symptom, heart ultrasound, Pulmonary Hypertension, Pelvic Adhesions, Late Infantile Neuronal Ceroid Lipfuscinsosis, Magnetic Resonance Imaging, pulmonary arterial pressure, Indikation: Diabetes - Typ II, Abdominal Surgery |
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| Treatment | 4D-flow sequence |
| Clinical Study Identifier | NCT05103189 |
| Sponsor | Centre Hospitalier Universitaire, Amiens |
| Last Modified on | 19 November 2021 |
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