Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms

  • End date
    Nov 1, 2026
  • participants needed
  • sponsor
    University of Miami
Updated on 7 October 2022


The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.

Condition Cerebral Aneurysm
Treatment Sirolimus, endovascular treatment, Microsurgical clipping
Clinical Study IdentifierNCT04141020
SponsorUniversity of Miami
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Undergoing one of the following procedures at Jackson Memorial Hospital
Clipping of an unruptured cerebral artery aneurysm
Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling)
≥ 18 years of age
Willing and able to give informed consent

Exclusion Criteria

Subjects meeting any of the following criteria will be excluded
Dissecting, traumatic, or mycotic brain aneurysm
Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test
Women who are breastfeeding
Any clinically significant psychiatric or psychological disease, which would preclude the patient from completing the protocol
Patients with known Human Immunodeficiency Virus (HIV) infection or other known immunodeficiency
Patient with renal or liver failure
Interstitial pneumonitis
History of lymphoma
History of skin cancer
Hypersensitivity to sirolimus
Severe or unstable concomitant condition disease or chronic condition, which in the opinion of the investigator could affect assessment of the safety or efficacy of study intervention
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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