Mediastinal Temperature and Post-operative Bleeding

  • STATUS
    Recruiting
  • End date
    Aug 15, 2025
  • participants needed
    100
  • sponsor
    Virginia Commonwealth University
Updated on 7 October 2022

Summary

This study will investigate how chest temperature relates to blood loss and blood clotting. Researchers will use infra-red thermometers to measure the temperature of the chest at the end of surgery see if this relates to the amount of blood collected from the surgical drains. In addition, researchers will test if warm irrigation of the chest increases the temperature of the chest and if this impacts blood loss.

Description

Low body temperature during surgery, defined as a temperature below 34 °C, occurs commonly in patients undergoing cardiac surgery due to the bypass machine and an open chest. Low body temperature has been associated with blood loss, but the relevant published data are inconclusive. Nevertheless, evidence suggests that blood loss during and after surgery are higher in low body temperature patients than in the normal body temperature patients. In addition, low body temperature can impair blood clotting. The clinical significance of this is high as it is well established that blood transfusion increases mortality after surgery.

Details
Condition Blood Loss, Surgical
Treatment saline irrigation
Clinical Study IdentifierNCT04933253
SponsorVirginia Commonwealth University
Last Modified on7 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients undergoing open cardiac surgery at VCU
Age18 to 80 years
American Society of Anesthesiologists Physical Status 1-3

Exclusion Criteria

history of excessive bleeding
partial thromboplastin time > 35 s
prothrombin time > 35 s
fibrinogen < 200 mg/dL
platelet count < 100,000/L
history of infection and fever within 4 weeks before surgery
use of steroid or immunosuppressant within 4 weeks before surgery
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