Precision Acupuncture in the Treatment of Peripheral Neuropathy After Taxanes Chemotherapy in Breast Cancer

  • STATUS
    Recruiting
  • End date
    Dec 1, 2023
  • participants needed
    54
  • sponsor
    Affiliated Hospital of Qinghai University
Updated on 18 November 2021
taxane

Summary

Precision Acupuncture in the Treatment of Peripheral Neuropathy After Taxane Chemotherapy in Breast Cancer

Description

Associated peripheral neuropathy in breast cancer patients has a significant impact on their quality of life and treatment compliance. Many studies have shown that acupuncture has a certain therapeutic effect on peripheral neuropathy. Studies have shown that taxane induced peripheral neuropathy in breast cancer is related to genetic factors. Based on SNPs related to peripheral neuropathy, this study screened SNPs related to peripheral neuropathy caused by taxane drugs, and established a prognostic model.

Eligible patients diagnosed with stage I, II or IIIA breast cancer and experiencing peripheral neuropathy for at least 2 weeks were assessed by the Functional Assessment of Cancer Therapy/Gynaecologic Oncology Group-NeurotoxicityFACT/GOG-Ntx) and the European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-CIPN twenty-item scale(EORTC QLQ-CIPN20). Likert level 5 and level 4 scores were used for all items in the above two scales. The investigators will temporarily divide the study into a group, and the investigators will increase the group if necessary. Laboratory personnel were blinded to all clinical and outcome data.

Details
Condition breast carcinoma, Breast Cancer, Breast Cancer Diagnosis, cancer, breast
Treatment Acupuncture
Clinical Study IdentifierNCT05099562
SponsorAffiliated Hospital of Qinghai University
Last Modified on18 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

The patient was at least 18 years old and had reported grade 1 or higher neuropathic symptoms for more than 2 weeks
Patients were screened for eligibility by the investigator prior to enrollment, including verification of baseline neuropathic symptoms
Patients had a diagnosis of stage I, II, or IIIA breast cancer
Have completed at least 2 weeks of chemotherapy
Higher scores indicate more severe symptoms
Voluntarily participate in the clinical trial and sign the informed consent form after informed consent (patients voluntarily accept the treatment and give informed consent)
Eastern Cooperative Oncology Group (ECOG ) score of physical condition (0-1)
Patients with previous local recurrence were eligible
The basic indexes were consistent, and the blood routine and ECG were normal

Exclusion Criteria

patients with needle phobia
Low platelet count (<50 000); co-morbidity with a bleeding disorder; comorbidity with thyroid dysfunction; pregnancy; haemoglobin levels <10 g/dl and haematocrit <30; anaemia on active pharmacological treatment or receiving blood transfusion or steroids
having metastatic or recurrent disease, history of preexisting peripheral neuropa- thy prior to chemotherapy, uncontrolled seizure disorder, unstable cardiac disease or myocardial infarction within 6 months prior to study entry
Being pregnant or nursing, or having used acupuncture for peripheral neuropathy within 6 months prior to study entry
Life expectancy <6 months
Lymphedema of limbs
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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