Early Onset Alzheimer's Disease study

Updated on 12 April 2023
cognitive impairment
mild cognitive impairment
Online studies
Accepts healthy volunteers


This study is looking for families who have one or more individuals with early-onset Alzheimer’s. The study is interested in the genetic factors across family members. This may help to develop methods for predicting or diagnosing early-onset Alzheimer’s.


Study schedule:
At the start of the study:
-You will have a screening telephone call.
-You will have in-person cognitive and neurological assessments.
-You will give a blood sample.

During the study:
-You will have a follow-up telephone interview every 18 months.
-You will repeat some or all of the study-start activities.

Study activities may include:
-Talking on the telephone.
-Having cognitive and neurological assessments, which may be in the form of interview-style conversations, paper-and-pencil questionnaires, computer tests, and/or other activities.
-Having a sample of blood drawn from your vein using a needle.

Treatment or experiment details:
-This study is interested in the genetic factors that influence early-onset Alzheimer’s.
-There is no experiment or treatment being tested in this study.

Additional details:
-Nuclear families (parent, child, siblings) as well as extended families (grandparental, cousins, uncle/aunt, etc.) may be eligible.
-Multiple family members must participate in the study together.

Condition Alzheimer's Disease, Mild Cognitive Impairment, Healthy Volunteers
Clinical Study IdentifierTX286255
Last Modified on12 April 2023


Yes No Not Sure

Inclusion Criteria

You are part of a family with early-onset Alzheimer’s (in other words, Alzheimer’s that was diagnosed when the individual was younger than 65). Examples of families who could be included are
A family with three or more individuals affected by early-onset Alzheimer’s, and one or more cognitively normal individual over age 60
A family with one or two related individuals with early-onset Alzheimer’s
A family with an individual with early-onset Alzheimer’s and an individual with late-onset Alzheimer’s
A family with an individual with early-onset Alzheimer’s and an individual with mild cognitive impairment

Exclusion Criteria

Your family does not have at least one individual with early-onset Alzheimer’s
Your family members have a non-Alzheimer’s cognitive diagnosis, such as frontotemporal dementia, traumatic brain injury, or vascular brain injury
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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