MRI QSM Imaging for Iron Overload

  • days left to enroll
  • participants needed
  • sponsor
    University of Wisconsin, Madison
Updated on 26 March 2022


The overall goal of this project is to develop and validate a novel technique for Magnetic Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM) of the abdomen, for non-invasive assessment of liver iron deposition. In this work, study team will develop and optimize advanced data acquisition and image reconstruction methods to enable QSM of the abdomen. Further, investigators will determine the accuracy, repeatability, and reproducibility of abdominal QSM for iron quantification in patients with liver iron overload.

Excessive accumulation of iron in various organs, including the liver, which affects both adult and pediatric populations, is toxic and requires treatment aimed at reducing body iron stores. Accurate assessment of liver iron concentration is critical for the detection and staging of iron overload as well as for longitudinal monitoring during treatment.

In summary, this project will develop a novel MRI-based QSM technique designed for the abdomen and will validate it in pediatric and adult patients with liver iron overload. Upon successful validation, QSM will provide accurate, repeatable, and reproducible quantification of LIC based on a fundamental property of tissue.

Condition Hemochromatosis, Iron Overload
Treatment Magnetic Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM)
Clinical Study IdentifierNCT04631718
SponsorUniversity of Wisconsin, Madison
Last Modified on26 March 2022


Yes No Not Sure

Inclusion Criteria

Ages 10 years or older at University of Wisconsin - Madison
Age 5 years or older at Stanford
Known or suspected iron overload

Exclusion Criteria

Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
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