The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and recommended Phase 2 dose (RP2D) of MK-0482. There are 2 parts of this study. Part 1 is a dose escalation which will follow an accelerated titration design (ATD) for participants with relapsed/refractory (R/R) AML or CMML. Part 2 is a dose expansion for participants with R/R AML.
| Condition | Relapsed or Refractory Acute Myeloid Leukemia, Relapsed or Refractory Chronic Myelomonocytic Leukemia |
|---|---|
| Treatment | MK-0482 |
| Clinical Study Identifier | NCT05038800 |
| Sponsor | Merck Sharp & Dohme LLC |
| Last Modified on | 8 September 2023 |
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