A Study to Evaluate MK-0482 for Relapsed/Refractory Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML) (MK-0482-002)

    Not Recruiting
  • End date
    Aug 25, 2025
  • participants needed
  • sponsor
    Merck Sharp & Dohme LLC
Updated on 8 September 2023


The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and recommended Phase 2 dose (RP2D) of MK-0482. There are 2 parts of this study. Part 1 is a dose escalation which will follow an accelerated titration design (ATD) for participants with relapsed/refractory (R/R) AML or CMML. Part 2 is a dose expansion for participants with R/R AML.

Condition Relapsed or Refractory Acute Myeloid Leukemia, Relapsed or Refractory Chronic Myelomonocytic Leukemia
Treatment MK-0482
Clinical Study IdentifierNCT05038800
SponsorMerck Sharp & Dohme LLC
Last Modified on8 September 2023

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