The Optimal Long Term Treatment Strategy of Anti-resorptive Medications---The Extension of Denosumab Sequential Therapy

  • End date
    Dec 31, 2030
  • participants needed
  • sponsor
    National Taiwan University Hospital
Updated on 1 November 2021
zoledronic acid


This study is to investigate whether the alternating use of Prolia (Denosumab) and Aclasta (Zoledronic acid) can continue to increase bone density.


This study intends to use a randomized trial to test whether the long-term treatment of Denosumab and Zoledronic acid can achieve sustained bone density progress and avoid the risk of rapid bone loss after the withdrawal of Denosumab.

Condition Osteopenia, bone mineral density, Osteoporosis, Bone Density, Bone Mass
Treatment Denosumab
Clinical Study IdentifierNCT05091086
SponsorNational Taiwan University Hospital
Last Modified on1 November 2021


Yes No Not Sure

Inclusion Criteria

Postmenopausal women or men over 50 years old
Denosumab treatment for at least two years and less than three years (up to five doses)

Exclusion Criteria

Estimated glomerular filtration rate <35 ml/min
Continuous steroid treatment, hormone therapy or other medical treatment affecting bone metabolism
Secondary osteoporosis
Metabolic bone diseases
Contraindications to ZOL
Patients older than 80 years old
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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