Zinc Effect on Inflammation and Cardiovascular Risk in HIV

  • End date
    Dec 22, 2022
  • participants needed
  • sponsor
    University Hospitals Cleveland Medical Center
Updated on 22 March 2022


To study the effect of short-term zinc supplementation on improving inflammation, metabolic, and cardiovascular risk among HIV infected patients on stable anti-retroviral therapy


This study will focus on subjects with documented zinc deficiency (levels <75 µg/dl) as group most likely to benefit from the zinc supplementation. The investigators also acknowledge that zinc may be beneficial in all HIV subjects, regardless of the plasma zinc level; however initial studies should be done in subjects with low zinc levels as they are more likely to benefit.

Condition Inflammation, Cardiovascular Diseases, Zinc Deficiency
Treatment Placebo, Zinc gluconate
Clinical Study IdentifierNCT05085834
SponsorUniversity Hospitals Cleveland Medical Center
Last Modified on22 March 2022


Yes No Not Sure

Inclusion Criteria

HIV-1 infection
Documentation of an HIV-1 RNA level of ≤400 copies/mL in the last 4 months prior to study entry
Male or Female age ≥18 years
Zinc level ≤0.75 mg/L in the last 60 days

Exclusion Criteria

Known cardiovascular disease
Uncontrolled diabetes
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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