Exploratory Study of Molecular Profile-Associated Evidence Guided Precision Therapy for Salivary Gland Cancer MAPS
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- STATUS
- Recruiting
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- End date
- Sep 19, 2023
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- participants needed
- 182
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- sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Summary
To explore the feasibility, efficacy and safety of determining the treatment regimen based on genomic profiling in patients with locally advanced and advanced salivary gland cancer.
Description
This is a prospective, open-label, non-randomized single-center study to evaluate the feasibility of using molecular profile-based evidence to guide personalized therapy for patients with incurable salivary gland carcinoma patients. Comprehensive Genomic Profiling is performed on tissue with assessment of tumor mutation burden (TMB) status, and additional PD-L1 immunohistochemistry testing. Study Committee or Molecular Tumor Board (MTB) will recommend matched therapy, if available, following analysis of patient genomic profiles. The final treatment administered will be based on the treating physician's choice with MTB advice, patient preference, comorbidity considerations, and available drug access. Access to medication followed real-world practice.
Details
| Condition | salivary gland cancer, Salivary Gland Disease, Oral Cavity Cancer, Oral Neoplasm, Oral Cancer, Saliva and Salivary Gland Dysfunction |
|---|---|
| Treatment | bicalutamide, Pyrotinib, Leuprorelin |
| Clinical Study Identifier | NCT05087706 |
| Sponsor | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University |
| Last Modified on | 28 October 2021 |
Eligibility
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