Exercise Training and Thrombotic Risk in Post-menopausal Women

  • End date
    Mar 1, 2023
  • participants needed
  • sponsor
    University of Copenhagen
Updated on 2 November 2021
blood clot
Accepts healthy volunteers


At menopausal transition, the risk of cardiovascular diseases increases. This is partly due to aging, but largely also the loss of estrogen, which has many positive effects on the circulation and protects against cardiovascular diseases. It has been suggested that the loss of estrogen may have a negative impact on the otherwise well-documented health promoting effects of exercise training, and that the time after menopause may be crucial for the effect of exercise training on the vascular function, and therefore also for the risk of thrombosis. Literature regarding the effect of exercise training on the risk of thrombosis is limited, and especially in women.

The purpose of the present study is to investigate whether the same effects of exercise training in relation to thrombosis is achieved if the exercise is initiated early compared to late after menopause. The aim is to provide knowledge-based recommendations regarding exercise. Teams sports will be used as the training intervention, because team sports benefits physical health and also includes a social element.


Part of the novelty of this project is to link functional measurements of cardiovascular health at whole body level to cell studies. Cells will be isolated from muscle samples obtained from the post-menopausal women before and after the training intervention. This will enhance the understanding of the changes that occur after prolonged loss of estrogen on thrombotic risk and vascular function, and whether exercise training can alter these parameters.

Condition vasodilatation, Exercise Training, clot, Vasodilation, Thrombosis, Menopause, blood clotting, Blood Clots, Vascular Dilation
Treatment Early and late postmenopausal women
Clinical Study IdentifierNCT04596501
SponsorUniversity of Copenhagen
Last Modified on2 November 2021


Yes No Not Sure

Inclusion Criteria

Age: 50-70 years
Physical activity 2 hours per week (except transportation by bike or by walking)
BMI 30

Exclusion Criteria

Age <50 years
Injuries that prevent the performance of team sports
Participation in other clinical projects
Smokes or has smoked within the last 10 years
On hormone therapy
Not entered menopause
Has chronic diseases that are not expected, cf. the groups sought. Including heart problems, atrial fibrillation, cancer, immune diseases and previous strokes with functionally significant sequelae
Being treated with oral steroids
Has alcohol / drug abuse or is being treated with disulfiram (Antabus)
Is unable to understand the contents of the document with informed consent or the experimental procedures
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