Prospective Comparison of 18F-FDG and 18F-FET PET for Response Evaluation in Patients With Primary Central Nervous System Lymphoma

  • End date
    Mar 31, 2023
  • participants needed
  • sponsor
    Asan Medical Center
Updated on 25 October 2021


The overall goal of this imaging trial is to prospectively compare the usefulness of 18F-FDG PET and 18F-FET PET in evaluating treatment response and predicting prognosis in patients with central nervous system lymphoma.

Condition Patients With Suspected or Diagnosed Central Nervous System Lymphoma
Treatment [18F]FET
Clinical Study IdentifierNCT05083936
SponsorAsan Medical Center
Last Modified on25 October 2021


Yes No Not Sure

Inclusion Criteria

In order to be eligible for participation in this trial, the subject must
Be 19 years of age
Patients diagnosed with central nervous system lymphoma by surgery/biopsy or suspected of central nervous system lymphoma by anatomical imaging examination such as MRI
Patients who have results or are planning to examine 18F-FDG PET in the above patients

Exclusion Criteria

The subject must be excluded from participating in the trial if the subject
fulfil any single criteria described below
Pediatric and adolescent patients under 19 years of age
The patient is pregnant, is attempting to become pregnant, or is nursing (breast-feeding) to children
Patients with diagnosed or suspected lymphoma lesions in organs other than the cetral nervous system
Based on the investigator's judgement, if the patient makes it impossible to collect complete data for a clinical trial due to personal or other reasons
Patients who cannot stably have PET/CT due to claustrophobia, dyskinesia, anxiety disorder, seizure, etc
Based on the investigator's judgement, if the patient has a serious and/or uncontrolled and/or unstable medical disease (e.g., congestive heart failure, acute myocardial infarction, severe lung disease, chronic renal disease or chronic liver disease, etc.)
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What happens next?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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