Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathy

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  • sponsor
    Sun Yat-sen University
Updated on 18 August 2022


The aim of this study is to evaluate the effects of subantimicrobial dose doxycycline (50 mg/d), administered for 12 weeks, on patients with mild Thyroid-Associated Ophthalmopathy (TAO).


Thyroid-Associated Ophthalmopathy is an autoimmune disease that can be treated by corticosteroids and surgery. But they often cause severe side-effects and are usually used for treating moderate-sever and sight-threatening TAO. Wait and see will be the first choice for the patient with mild TAO.

Subantimicrobial dose (SD) doxycycline displays a strong anti-inflammatory and immunomodulatory function, which is independent of its antibiotic properties. Data from clinical trials demonstrated that SD doxycycline was effective in moderating inflammation in a variety of autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, rosacea and periodontitis.

We propose to test the effect of subantimicrobial dose doxycycline for mild TAO.

Condition immun, immune disorder, immune dysfunction, hereditary eye diseases, immune disease, endocrine diseases, GRAVES' DISEASE, autoimmune diseases, Hyperthyroidism, immune disorders, Thyroid Disorders, autoimmune hyperthyroidism, Autoimmunity, graves, Graves' ophthalmopathy, autoimmune disorders, Thyroid disorder, endocrine disease, endocrine disorders, autoimmune disorder, Disorder of immune system, Endocrine disorder, Thyroid Disease, Autoimmune Disease, immunologic disease, Hyperthyroid, grave disease, endocrinopathy, Autoimmune disease
Treatment Placebo, Doxycycline Hyclate
Clinical Study IdentifierNCT02203682
SponsorSun Yat-sen University
Last Modified on18 August 2022

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