Prospective Evaluation of Targeted Axillary Dissection (TAD) (TAD)

  • STATUS
    Recruiting
  • End date
    Mar 13, 2025
  • participants needed
    45
  • sponsor
    University of Miami
Updated on 13 April 2022

Summary

The purpose of this research is to evaluate how to manage the axillary lymph nodes in patients with breast cancer. The investigators will determine if a sampling of the lymph nodes under the arm will give the information necessary to determine if fewer lymph nodes can be removed.

Details
Condition Breast Cancer
Treatment Axillary dissection
Clinical Study IdentifierNCT04998682
SponsorUniversity of Miami
Last Modified on13 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Women or men greater than or equal to 18 years
Histologically confirmed invasive adenocarcinoma of the breast
Clinical T0-4 N2-3 M0 at diagnosis (American Joint Committee on Cancer, 7th Edition)
Assessment for cN2 disease will be performed by clinical exam and imaging. Patients should have pathologic level 1 and/or 2 axillary lymph nodes which are fixed/matted on physical exam
Cross-sectional imaging will be used to identify advanced nodal disease involving the axilla, infraclavicular, supraclavicular, and internal mammary regions, cN3 disease
Patients must have biopsy proven involvement of the axillary lymph nodes
Receipt of standard multiagent chemotherapy +/- targeted therapy based on tumor subtype
Candidate for surgical management of breast cancer
Ability to understand and willingness to sign a written informed consent document

Exclusion Criteria

History of allergic reactions or hypersensitivity to radioactive lymph node mapping agents or blue dye
Pregnancy
Clear my responses

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