Multisession Radiosurgery in Residual/Recurrent Grade II Meningiomas.

  • STATUS
    Recruiting
  • End date
    May 24, 2023
  • participants needed
    25
  • sponsor
    Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Updated on 24 October 2021

Summary

Fractionated radiosurgery will be delivered to atypical meningioma lesions in salvage setting for patients who present post-surgical residual lesion or develop recurrence.

Description

Meningioma is the most common intracranial tumor (1). World Health Organization (WHO) grade II (atypical) meningioma recurs more frequently than WHO grade I (benign) meningioma, and patients with subtotally resected atypical meningioma should be treated with adjuvant radiation therapy (2). However, many atypical meningiomas can be gross totally resected, and whether to administer radiation to this population remains unclear. Apart from extent of resection, clinical characteristics such as age and gender and tumor-related characteristics such as tumor size and location have poor predictive capacity to determine which lesions will recur.

The lack of professional consensus on the role of adjuvant radiation therapy (RT) derived from the heterogeneity and retrospective nature of the published data: standard fractionation fails to demonstrate a benefit in term of local control and survival.

Recent advances in radiotherapy technology (staged radiosurgery) give the possibility to reach high dose levels only in tumor volume and in the same time to save the surrounding healthy tissues.

The purpose of this study is to verify the related toxicity of a new radiotherapy protocol and as second end point to evaluate the efficacy on disease local control at 3 years.

Details
Condition Atypical Meningioma
Treatment radiosurgery
Clinical Study IdentifierNCT05081908
SponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Last Modified on24 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients had residual or recurrent atypical meningioma (grade II) after surgery (Simpson score)
Age: 18 years old
Karnofsky performance Status ( KPS) 70
Written consent

Exclusion Criteria

Pregnancy
Neurofibromatosis type 2 (NF2)
Concomitant aggressive haematological or solid neoplasm
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