Early Clinical Outcome of Medial Unicompartmental Knee Arthroplasty (UKA) and High Tibial Osteotomy (HTO) for the Treatment of Anteromedial Osteoarthritis (AMOA) in Chinese Population

  • days left to enroll
  • participants needed
  • sponsor
    Zimmer Biomet
Updated on 23 October 2022
total knee replacement
partial knee replacement
joint reconstruction


The purpose of this study is to compare the performance and safety of medial UKA and HTO in the treatment of AMOA in term of functional outcome, radiographic assessment, range of motion, postoperative complications, revision rate and relevant health economics outcome.


The purpose of this study is to compare the outcomes of medial UKA and HTO in the treatment of AMOA by investigating the performance of these 2 procedures in terms of functional outcome, radiographic assessment, range of motion, postoperative complications, revision rate and relevant health economics outcome, then identify factors associated with better clinical performance. It is aimed to provide evidence-based guidelines for selecting the appropriate procedure in managing AMOA in Chinese population based on the findings of this study.

The secondary endpoints will include:

  1. Pain Numerical Rating Scale (NRS)
  2. SF-12 Health Survey
  3. Radiographic assessment includes pre-op and post-op mechanical femorotibial angle (mFTA), patella height, patellofemoral medial and lateral articular surfaces, and displacement angle of patella
  4. Range of motion
  5. Adverse event rate and classification (including complication)
  6. Operating time
  7. Total blood loss (BRECHER formula)
  8. Revision rate

Health economic outcomes based on hospital discharge days, recovery time, physiotherapy and complications/ reoperations will also be analyzed.

Condition Knee Osteoarthritis
Clinical Study IdentifierNCT04518111
SponsorZimmer Biomet
Last Modified on23 October 2022


Yes No Not Sure

Inclusion Criteria

Patient is aged 18 to 85 years old, inclusive
Patients who diagnosed with AMOA of the knee, and have undergone Open Wedge HTO, or primary unilateral partial knee arthroplasty with Oxford Partial Knee with Microplasty® instrumentation in accordance to indications of UKA and the following radiographic assessments in the knee joint
exposed bone on both the femur and tibia in the medial compartment
functionally intact ACL
full thickness lateral cartilage (ignore osteophytes)
functionally normal MCL: correctable deformity (normal medial opening)
acceptable patellofemoral joint: normal, medial facet OA with or without bone loss, lateral facet OA without bone loss
UKA or HTO procedure completed one year prior to study participation
Patient provides written informed consent by signing and dating the Institutional Review Board/Ethics Committee (IRB/EC) approved informed consent form

Exclusion Criteria

Has undergone UKA but met any of the contraindications included in the product labeling of Oxford Partial Knee system
Has rheumatoid arthritis or other forms of inflammatory joint disease
Uncooperative or with neurologic disorders who are incapable of following directions
Has a diagnosed systemic disease that could affect his/her safety or the study outcome
Anterior cruciate ligament and posterior cruciate ligament injury, collateral ligament instability
Known to be pregnant
Prisoner or known alcohol / drug abuser
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note