Dysregulated Urea-synthesis at Terminal Uremia

  • STATUS
    Recruiting
  • End date
    Dec 1, 2024
  • participants needed
    16
  • sponsor
    University of Aarhus
Updated on 22 October 2021
urea
chronic hemodialysis
Accepts healthy volunteers

Summary

This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"

Details
Condition Nephropathy, Kidney Disease (Pediatric), Uremia, Disorders of urea cycle metabolism, Urea Cycle Disorder, Kidney Disease
Treatment Aminoacid, alanine-infusion
Clinical Study IdentifierNCT05076318
SponsorUniversity of Aarhus
Last Modified on22 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age > or equal to 18 years
Chronic hemodialysis during 3 months
Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby

Exclusion Criteria

Active infection
Conditions with vomiting or diarrhea
Diabetes
Active disease being treated with chemotherapy, radiationtherapy, biologic- or similar treatments. Disease under observation can be included
Liver disease
Vessels on the upper extremities not suited for cannulation
Prednisolone treatment during the last 8 weeks
Pregnancy
BMI > or equal to 30 or < or equal to 18
Physically or mentally condition that does not allow the project to be completed
Language-difficulties that does not allow the project to be completed
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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