Dysregulated Urea-synthesis at Terminal Uremia

  • End date
    Dec 1, 2024
  • participants needed
  • sponsor
    University of Aarhus
Updated on 22 October 2021
chronic hemodialysis
Accepts healthy volunteers


This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"

Condition Nephropathy, Kidney Disease (Pediatric), Uremia, Disorders of urea cycle metabolism, Urea Cycle Disorder, Kidney Disease
Treatment Aminoacid, alanine-infusion
Clinical Study IdentifierNCT05076318
SponsorUniversity of Aarhus
Last Modified on22 October 2021


Yes No Not Sure

Inclusion Criteria

Age > or equal to 18 years
Chronic hemodialysis during 3 months
Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby

Exclusion Criteria

Active infection
Conditions with vomiting or diarrhea
Active disease being treated with chemotherapy, radiationtherapy, biologic- or similar treatments. Disease under observation can be included
Liver disease
Vessels on the upper extremities not suited for cannulation
Prednisolone treatment during the last 8 weeks
BMI > or equal to 30 or < or equal to 18
Physically or mentally condition that does not allow the project to be completed
Language-difficulties that does not allow the project to be completed
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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