TXA in Revision Total Shoulder Arthroplasty

  • End date
    Nov 24, 2025
  • participants needed
  • sponsor
    NYU Langone Health
Updated on 7 October 2022


This is a phase IV, randomized, single-blind, single-center study comparing calculated total blood loss, surgical drain output and hematoma formation in patients who receive 2 doses of Tranexamic Acid (TXA) versus control group undergoing revision total shoulder arthroplasty. Patients will be randomized to either receive 2 doses of IV TXA, first dose prior to surgical incision and second dose given 3 hours later or to the control group, where no TXA will be administered.


The objectives of the study are to compare the effectiveness of IV TXA on reducing calculated total blood loss, surgical drain output and hematoma formation in patients undergoing revision total shoulder arthroplasty.

Condition Arthropathy Shoulder
Treatment Tranexamic Acid
Clinical Study IdentifierNCT04650698
SponsorNYU Langone Health
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Patients older than 18 years old
Patients younger than 90 years old
Patients undergoing scheduled revision total shoulder arthroplasty
Patients who consent to be randomized

Exclusion Criteria

Patients younger than 18
Patients older than 90 years old
Patients who are pregnant or breast-feeding women
Patients who are allergic to tranexamic acid
Patients with proximal humerus fracture or fracture sequelae
Patients who use estrogen containing medications (i.e. oral contraceptive pills)
Patients who have acquired disturbances of color vision
Patients with a history of any of the following diagnosis: '
Subarachnoid hemorrhage
Active intravascular clotting
Severe pulmonary disease (FEV <50% normal)
Plasma creatinine > 115 μmol/L in males, > 100 μmol/L in females, or hepatic failure)
(Renal impairment serum creatinine > 1.5 times the upper limit of normal NYU)
Preoperative anemia [Hemoglobin (Hb) < 11g/dL in females, Hb < 12 g/dL in males]
Patients who refuse blood products
Patients undergoing hormone replacement therapy
Patients with diagnosed or self-reported cognitive dysfunction
Patients who are unable to understand or follow instructions
Patients with severe liver disease, renal insufficiency, congestive heart failure, and/or significant heart disease
Patients with BMI over 50
Any patient that the investigators feel cannot comply with all study related procedures
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