Combined Flow and Pressure Study of Craniospinal Dynamic (REVERT)

  • End date
    Sep 20, 2024
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire, Amiens
Updated on 25 January 2022
cognitive impairment


Normal pressure hydrocephalus (NPH) can cause a type of dementia. However, this type of dementia is the only one that is reversible. To treat this dementia it is necessary to evacuate the accumulation of CSF from the brain to another body cavity using a device called a shunt. But the implantation of this shunt is only effective when the cause of the pathology is an alteration of the normal circulation of the CSF. To diagnose these patients, morphological MRI and lumbar puncture are standard approaches used but remain perfectible in diagnostic terms.

The main objective is to build a new model of the interaction of intracranial pressures and fluids in order to obtain a new parameter allowing to obtain information on the cerebral biomechanics.

Condition Intracranial Pressure, Cerebral Blood Flows, Infusion Test, Phase Contrast MRI, Hydrocephalus, Dementia
Clinical Study IdentifierNCT05068128
SponsorCentre Hospitalier Universitaire, Amiens
Last Modified on25 January 2022


Yes No Not Sure

Inclusion Criteria

age > 55 years
Patients with suspected active hydrocephalus (HA) known as "normal pressure
Ventricular dilatation: Evans index > 0.3
Patients with cognitive impairment, and/or gait disorders and/or urinary incontinence or a combination of these three symptoms
Absence of other neurological diseases that could cause ventriculomegaly
Information and collection of the patient's non opposition

Exclusion Criteria

All patients with neurological disease other than active hydrocephalus will be excluded
Individuals who cannot tolerate an MRI examination
All individuals with implants, pacemakers, prostheses and ferromagnetic objects
Patients under guardianship, curators or safeguard of justice
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