A Study of TAS2940 in Participants With Locally Advanced or Metastatic Solid Tumor Cancer
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- STATUS
- Recruiting
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- End date
- Jun 11, 2025
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- participants needed
- 42
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- sponsor
- Taiho Oncology, Inc.
Summary
This is a first-in-human, open label, multicenter study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and the preliminary antitumor activity of TAS2940 in patients with advanced or metastatic solid tumors who are not candidates for approved or available therapies.
Description
TAS2940 is a small molecule inhibitor of ERBB family proteins HER2 and EGFR. It has not been evaluated in human subjects yet. The study will be conducted in 2 parts, dose escalation and dose expansion. The dose escalation part will assess the safety and determine the maximum tolerated dose, the recommended phase 2 dose and the recommended dosing regimen of TAS2940 administered orally. The dose expansion part will assess preliminary anti-tumor activity in select solid tumors characterized by HER2 or EGFR aberrations.
Details
| Condition | Solid Tumor, Glioblastoma, Non-small Cell Lung Cancer, Breast Cancer |
|---|---|
| Treatment | TAS2940 |
| Clinical Study Identifier | NCT04982926 |
| Sponsor | Taiho Oncology, Inc. |
| Last Modified on | 11 March 2022 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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