Pain Modulation - Experimental Assessments Using Different Modalities

  • STATUS
    Recruiting
  • End date
    May 23, 2023
  • participants needed
    705
  • sponsor
    Schweinhardt Petra
Updated on 23 March 2022
cold
back pain
spinal cord
low back pain
Accepts healthy volunteers

Summary

The goal of this study is to investigate how different painful stimuli are processed and modulated in the nervous system. In various pain conditions, including low back pain, often no specific source can be identified as the cause of the pain. Scientific findings point towards a possible involvement of sensitization processes in the central nervous system (spinal cord and brain) that can contribute to the development and persistence of chronic pain. There is a need for reliable and well established experimental methods to better investigate and understand these processes. Frequently used methods comprise the application of thermal, mechanical or electrical stimulations. These modalities are processed in different parts of the nervous system, each allowing its own conclusions. This can be an advantage, but it also poses a challenge regarding comparability and generalizability of obtained results.

This study aims to apply and compare various experimental methods in people without and people with low back pain and shed light on the methodological differences. In the future, this could enable better identification and characterization of sensitization processes in the nervous system and build the basis for individually adapted, mechanism-targeted treatments with better patient outcomes.

Details
Condition Low Back Pain, Compare Pain Modulation Assessments in Pain-free Cohorts
Treatment Cold water bath, Neutral Water Bath
Clinical Study IdentifierNCT04323293
SponsorSchweinhardt Petra
Last Modified on23 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

German or English proficiency
Informed consent
primary pain complaint localized between the 12th rib and the gluteal fold
low back pain for more than one week
low back pain clinically not attributable to "red flags" (including infection, trauma, fractures, inflammatory)

Exclusion Criteria

unable to give informed consent (e.g. due to language problems)
any neurological condition
any major medical or psychiatric condition (e.g. severe heart disease, diabetes, autoimmune disorders, major depressive disorder), any chronic pain condition other than low back pain
pregnancy
Radiating pain below knee level (radicular pain)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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