Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline

  • STATUS
    Recruiting
  • End date
    Sep 25, 2023
  • participants needed
    25
  • sponsor
    State University of New York - Downstate Medical Center
Updated on 20 October 2021

Summary

Adults with known respiratory allergy/asthma with known skin test sensitization will undergo repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms). Each site will be challenged with up to three known allergens, saline and histamine controls. Mean wheal diameter after 20 minutes challenge will be determined. This is followed by placement of minocycline cream (0%, 1%, 2%, 3%), placed in randomized fashion at each of 1 of 4 skin test sites. Measurement of subsequent wheal diameter will be done at 30 minutes, 60 minutes and 24 hours.

Description

Adults with known respiratory allergy/asthma with known skin test sensitization will undergo repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms). Each site will be challenged with up to three known allergens, saline and histamine controls. Mean wheal diameter after 20 minutes challenge will be determined. This is followed by placement of minocycline cream (0%, 1%, 2%, 3%), placed in randomized fashion at each of 1 of 4 skin test sites. Measurement of subsequent wheal diameter will be done at 30 minutes, 60 minutes and 24 hours.

In addition, itch assessment at each site will be done at baseline, 30 minutes, 60 minutes and 24 hours using VAS and questionnaire.

Details
Condition Allergies & Asthma, Asthma, bronchial asthma, asthmatic, Allergic Rhinitis, Asthma (Pediatric)
Treatment placebos, Minocycline Topical
Clinical Study IdentifierNCT04202263
SponsorState University of New York - Downstate Medical Center
Last Modified on20 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult ( ages 18-75) outpatients with diagnosis of allergic rhinoconjunctivitis and/or asthma who have previously undergone epicutaneous skin prick testing with detection of at least one allergen positive

Exclusion Criteria

Subjects who are unable/unwilling to undergo cessation of oral antihistamines for five days prior to testing
Current use of oral steroids or other systemic immunosuppressants, including omalizumab (anti-IgE therapy) and anti-IL-5 therapy
Allergic asthmatics who have current uncontrolled asthma
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