Transcutaneous Spinal Neuromodulation to Normalize Autonomic Phenotypes

  • End date
    May 31, 2023
  • participants needed
  • sponsor
    Spaulding Rehabilitation Hospital
Updated on 28 October 2022
spinal cord
spinal cord disorder
spinal cord stimulation
autonomic dysreflexia
neurologic findings
spinal injury
Accepts healthy volunteers


This study looks to characterize autonomic nervous system dysfunction after spinal cord injury and identify the potential role that transcutaneous spinal cord stimulation may play at altering neuroregulation. The autonomic nervous system plays key parts in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with spinal cord injury typically encounter complications. For both individuals with spinal cord injury and uninjured controls, experiments will utilize multiple parallel recordings to identify how the autonomic nervous system is able to inhibit and activate sympathetic signals. The investigators anticipate that those with autonomic dysfunction after spinal cord injury will exhibit abnormalities in these precise metrics. In both study populations, transcutaneous spinal cord stimulation will be added, testing previously advocated parameters to alter autonomic neuroregulation. In accomplishing this, the investigators hope to give important insights to how the autonomic nervous system works after spinal cord injury and if it's function can be improved utilizing neuromodulation.

Condition Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic; Hypotension, Neurogenic
Treatment Transcutaneous spinal cord stimulation, Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
Clinical Study IdentifierNCT04858178
SponsorSpaulding Rehabilitation Hospital
Last Modified on28 October 2022


Yes No Not Sure

Inclusion Criteria

All participants
age 18-30 years old
Participants with spinal cord injury
Adult onset, traumatic spinal cord injury
Time since injury 1 year, in an effort to limit baroreflex desensitization
American Spinal Injury Association Impairment Scale, A, to limit potential confounders
Neurological level of injury, T1-T6, as defined by the International Standards for Neurological Classification of Spinal Cord Injury

Exclusion Criteria

History of cardiovascular disease, hypertension, neurologic disorders (with exception of spinal cord injury), or diabetes
Women who are pregnant or lactating
Currently taking blood thinners
Taking anti-hypertensive or other medication that could influence any of the dependent autonomic variables
Clear my responses

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