Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis

  • End date
    Jan 18, 2024
  • participants needed
  • sponsor
    University Hospital, Tours
Updated on 18 October 2021
primary lateral sclerosis
Accepts healthy volunteers


Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting the motor neuron. Currently, there is no diagnostic test and no examination that can predict the evolution of this pathology. The search for diagnostic and prognostic biomarkers is therefore essential for a better understanding of the pathophysiology of ALS, which remains poorly understood, and also for better clinical management. The ocular surface, made up of liquid elements, tears, and cells, is an accessible anatomical-physiological entity that has demonstrated its usefulness in the identification of biomarkers in neurodegenerative diseases such as Parkinson's or Alzheimer's. To date, no study has explored the ocular surface as a biomarker in ALS

Condition Amyotrophic Lateral Sclerosis (ALS), Spinal Cord Disorders, Myelopathy, lou gehrig's disease, Amyotrophic Lateral Sclerosis
Treatment Measure of visual acuity, Interferometry, Interferometry, Samples of basal tears, Central corneal sensitivity, Slit lamp examination and undilated fundus, Conjunctival impression, Evaluation of the corneal innervation
Clinical Study IdentifierNCT04953286
SponsorUniversity Hospital, Tours
Last Modified on18 October 2021


Yes No Not Sure

Inclusion Criteria

No diagnosed neurological pathology
years of age and 75 years of age
Patient affiliated with a social security plan
Informed consent signed by the participant

Exclusion Criteria

Pregnant or breastfeeding woman
Treatment likely to have a neuroprotective effect
Any eye drops or treatments that may interfere with tear production
Lens wearer
Eye surgery 3 months
Any ocular pathology except ametropia, oculomotor disorder, amblyopia
Any general pathology with ocular repercussions
Protective measure of guardianship or curator
Clear my responses

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