Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumors
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- STATUS
- Recruiting
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- End date
- Dec 31, 2029
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- participants needed
- 122
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- sponsor
- First Affiliated Hospital of Zhejiang University
Summary
The R0 resection rate of gastrointestinal stromal tumor (GIST) with high recurrence risk was relatively low, and the relapse-free survival rate was relatively low, which needed to be further improved. A few retrospective analyses and a small sample of prospective studies have found that neoadjuvant therapy with imatinib mesylate can improve R0 resection rates. Whether neoadjuvant therapy prolongs long-term survival remains unclear. The primary objective of this study was to evaluate 5-year progression-free survival (PFS) for GIST patients with high recurrence risk after neoadjuvant treatment with imatinib mesylate.
Details
| Condition | gastrointestinal stromal tumors, neoadjuvant treatment, Disease-Free Survival, Neoadjuvant Therapy, gastrointestinal stromal tumor, gist, induction therapy |
|---|---|
| Treatment | Imatinib |
| Clinical Study Identifier | NCT04933669 |
| Sponsor | First Affiliated Hospital of Zhejiang University |
| Last Modified on | 17 October 2021 |
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