Pentoxifylline Add-on Therapy for Schizophrenia

  • STATUS
    Recruiting
  • days left to enroll
    83
  • participants needed
    90
  • sponsor
    Mazra Mental Health Center
Updated on 18 October 2021
immunomodulator

Summary

The etiology and pathogenesis of schizophrenia remain unclear. The immune dysfunction hypothesis for schizophrenia has attracted increasing attention from researchers, and substantial evidence suggested that the levels of TNF- and other cytokines are markedly elevated in patients with schizophrenia. The investigators aim to evaluate the adjuvant therapeutic effect of Pentoxifylline, a TNF- inhibitor that crosses the blood-brain barrier, in a randomized, double-blind, 6-week trial. Individuals with schizophrenia will receive either Pentoxifylline or a matching placebo as an add-on treatment to antipsychotic agents. Subjects' positive and negative symptoms and plasma concentration of neuroinflammatory markers will be monitored at baseline and every two weeks until the end of the trial.

Description

Ninety schizophrenic patients will be randomized to a Pentoxifylline (400 mg twice a day) or placebo treatment for six weeks. Pentoxifylline and placebo will be added to the current antipsychotic drug treatment. Participants will be asked to fill a socio-demographic questionnaire and to undergo a clinical differential diagnosis using the Symptoms Check List (SCL)-90, Clinical Global Impression (CGI), positive and negative symptoms scale (PANSS), and Hamilton depression rating scale (HAM-D). Following baseline evaluation, participants will be monitored for symptoms every two weeks until the end of the trial (overall three visits) using CGI, PANSS, and HAM-D. Adverse effects will be documented every visit using the Treatment Emergent Symptom Scale. Finally, yet importantly, a blood sample will be collected at baseline and every two weeks until the end of the trial to study the treatment effect on inflammatory markers.

Details
Condition schizophrenia disorders, Schizophrenia and Schizoaffective Disorders, Schizophrenia and Schizoaffective Disorders (Pediatric), Schizophrenia
Treatment Oxopurin
Clinical Study IdentifierNCT05073640
SponsorMazra Mental Health Center
Last Modified on18 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients meeting the DSM-V criteria for schizophrenia spectrum disorders
Clinical Global Impression (CGI) score 4 and 6 at screening
Initiated treatment with a stable dosage of typical and/or atypical antipsychotic medication for at least four weeks

Exclusion Criteria

Previous sensitivity to pentoxifylline (PTF)
Chronic immune and/or inflammatory diseases (such as rheumatoid arthritis, systemic lupus erythematosus, chronic inflammatory bowel disease)
Consumption for > 3 consecutive days of any immune-modulating or anti-inflammatory drug in the last month
Current active and persistent substance and/or alcohol abuse
Any severe, unstable medical condition (e.g., cardiovascular disorders, diabetes mellitus, respiratory diseases, cancer)
Obesity (body mass index > 30)
Cognitive dysfunction such as retardation
Known or suspected pregnancy or breastfeeding women
Lactose intolerance or sensitivity
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